Publications
Books and Monographs
  • R. Deac, D. Simionescu, "Heart biomechanics", In BIOMECANICS, 1989, Romanian Academy Press, Bucharest, pp.127-140. (in Romanian).
  • Simionescu D, Simionescu A, Deac R, "Molecular pathology of biomaterials, in "Cell adhesion and the extracellular matrix". C. Cruce, A. Simionescu, D. Simionescu et.al., (eds), AIUS Publishers, Craiova, Romania, 1997. (in Romanian).
  • Simionescu D. "Artificial heart valves ". By invitation; Encyclopedia of Biomedical Engineering, Metin Akay, editor. John Wiley and Sons, Inc., Hoboken, NJ. 2006. 
  • Dan Simionescu, Agneta Simionescu, book editors. InTech - Open Access Publisher, Rijeka, Croatia. Title, “Vasculogenesis and Angiogenesis – from Embryonic Development to regenerative Medicine”. ISBN 978-953-307-882-3. (November 2011).

Refereed Journal Publications

  • D. Simionescu, M. Simionescu. "Differentiated distribution of the cell surface charge on the alveolar capillary unit".  Microvascular Research, 1983, 25, 85-100.
  • D. Simionescu, R. Alper and N.A. Kefalides. "Partial characterization of a low molecular weight proteogly­can isolated from bovine parietal pericardium". Biochemical and Biophysical Research Communications, 1988, 151, 1, 480-486.
  • D. Simionescu, R.V. Iozzo and N.A. Kefalides. "Bovine pericardial proteoglycan; biochemical, immunochemical and ultrastructural studies", Matrix, 1989, 9, 301-310.
  • D. Simionescu, N.A.  Kefalides. "Biosynthesis of proteoglycans and interstitial collagens by bovine pericardial fibroblasts", Experimental Cell Research, 1991, 195, 171-176.
  • Simionescu A, D. Simionescu, R. Deac. "Lysine-enhanced glutaral­dehyde crosslinking of collagenous biomaterials", Journal of Biomedical Materials Research, 1991, 25, 1495-1505.
  • D. Simionescu, A. Simionescu, R. Deac. "Mapping of glutaraldehyde-treated bovine pericardium for use as bioprosthetic cardiac valves", Journal of Biomedical Materials Research, 1993,27, 6, 697-704.
  • D. Simionescu, A. Simionescu, R. Deac, "Remnant proteolytic ac­tivities in glutaraldehyde treated bovine pericardium and in ex­planted cardiac bioprostheses", Journal of Biomedical Materials Research, 1993, 27, 6, 821-829.
  • D. Simionescu, R. Deac, A. Simionescu, "Inhibition of extracellular-matrix degrading proteases in pericardial derived cardiovascular bioprostheses", Journal of Material Science; Materials in Medicine, 1994, 5, 748-751.
  • R. Deac, D. Simionescu, D. Deac, "New evolution in mitral physiology and surgery; mitral stentless pericardial valve", Annals of Thoracic Surgery, 1995, 60, S433-S438.
  • A. Simionescu, D. Simionescu, R. Deac, "Matrix metalloproteinases in the pathology of natural and bioprosthetic cardiac valves". Cardiovascular Pathology, 1996, 5, 323-332.
  • A. Simionescu, D. Simionescu, R. Deac, "Biochemical pathways of tissue degeneration in bioprosthetic cardiac valves; the role of matrix metalloproteinases". ASAIO Journal, 1996, 42, 5, M561-M567.
  • M. Bracher, D. Simionescu, A. Simionescu, N. Davies, P. Human, P. Zilla, “The role of matrix metalloproteinases in tissue valve degeneration – a mini-review”. Journal of Long Term Effects of Medical Implants, 2001, 11(3-4), 221-230.
  • D. Simionescu, J. Lovekamp, N. Vyavahare, “Degeneration of stentless bioprosthetic heart valves is initiated during tissue preparation; an ultrastructural study. Journal of Heart Valve Disease, 2003, 12, 226-234.
  • D. Simionescu, J. Lovekamp, N. Vyavahare, “Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves”. Journal of Biomedical Materials Research, 2003, 66A, 755-763.
  • D. Simionescu, J. Lovekamp, N. Vyavahare, “Glycosaminoglycan-degrading enzymes in porcine aortic heart valves; implications for bioprosthetic heart valve degeneration. Journal of Heart Valve Disease, 2003, 12, 217-225.
  • J. Isenburg, D. Simionescu, N. Vyavahare, “Elastin stabilization in cardiovascular implants; improved resistance to enzymatic degradation by treatment with tannic acid”. Biomaterials, 2004, 25(16), 3293-3302.
  • Simionescu D, Lovekamp JJ, Vyavahare NR, "Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves". Journal of Biomedical Materials Research, 2003, 66(4), 755-763.
  • Simionescu D, "Prevention of calcification in bioprosthetic heart valves: challenges and perspectives". By invitation. Expert Opinions in Biological Therapy, 2004, 4(12), 1971-1985.
  • Basalyga DM, Simionescu D, Xiong W, Baxter BT, Starcher BC, Vyavahare NR, "Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases", Circulation, 2004, 110(22), 3480-3487.
  • Lu Q, Ganesan K, Simionescu D, Vyavahare NR, "Novel porous aortic elastin and collagen scaffolds for tissue engineering", Biomaterials, 2004, 25(22), 5227-5237.
  • Bailey M, Pillarisetti S, Jones P, Xiao H, Simionescu D, Vyavahare N, "Involvement of matrix metalloproteinases and tenascin-C in elastin calcification", Cardiovascular Pathology, 2004, 13(3), 146-155.
  • Isenburg JC, Simionescu D, Vyavahare NR, "Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid", Biomaterials, 2004, 25(16), 3293-3302.
  • Simionescu D, Lu Q, Song Y, Lee JS, Rosenbalm TN, Kelley C, Vyavahare NR, "Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds", Biomaterials, 2005, 27, 702-713.
  • Lovekamp JJ, Simionescu D, Mercuri J, Zubiate B, Sacks M, Vyavahare NR, “Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves”, Biomaterials, 2005, 27, 1507-1518.
  • Isenburg J, Simionescu D, Vyavahare N, "Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall", Biomaterials, 2005, 26(11), 1237-1245.
  • Lee JS, Basalyga D, Simionescu D, Vyavahare NR, “Mechanisms of elastin calcification in rat subdermal model: gene expression associated with elastin degeneration and ectopic osteogenesis”, American Journal of Pathology, 2006, 168, 490-498.
  • Isenburg JC, Simionescu D, Ramachandani N, Vyavahare NR, “Structural requirements for stabilization of vascular elastin by polyphenolic tannins”, Biomaterials, 2006, 19, 3645-3651.
  • Kasyanov V, Isenburg JC, Draughn AR, Hazard S, Hodde J, Iveta O, Halkes B, Pieters R, Simionescu D, Markwald RR, Mironov V, “Tannic acid mimicking dendrimers as a small intestine submucosa stabilizing nano-agent”, Biomaterials, 2006, 27, 745-751.
  • Simpson CL, Lindley S, Eisenberg C, Basalyga DM, Starcher BC, Simionescu D, Vyavahare NR, “Toward cell therapy for vascular calcification: osteoclast-mediated demineralization of calcified elastin”, Cardiovascular Pathology, 2007, 16(1), 29-37.
  • Mercuri J, Lovekamp J, Simionescu D, Vyavahare NR, “Targeted crosslinking of glycosaminoglycans for bioprosthetic heart valve stabilization”, Biomaterials, 2007, 28(3), 496-503.
  • Isenburg J, Simionescu D, Starcher B, Vyavahare N, “Elastin stabilization for treatment of abdominal aortic aneurysms”, Circulation, 2007, 115(13), 1729-37.
  • Kurane A, Simionescu D, Vyavahare N, “In vivo cellular repopulation of tubular elastin scaffolds mediated by basic fibroblast growth factor”, Biomaterials, 2007, 28(18), 2830-2838.
  • Raghavan D, Simionescu D, Vyavahare N, “Neomycin prevents enzyme-mediated glycosamino-glycan degradation in bioprosthetic heart valves”, Biomaterials, 2007, 28(18), 2861-8.
  • Simionescu A, Simionescu D, Vyavahare N, “Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-beta1: role of myofibroblasts in vascular calcification”, American Journal of Pathology, 2007, 171(1), 116-23.
  • Y.Y. Yuan, P.J. Kostenuik, S. Morony, D. Simionescu, D.M. Basalyga, T.A. Bateman, “Skeletal deterioration induced by RANKL infusion; a model for high-turnover bone disease”, Osteoporosis International, 2008, 19(5), 625-35.
  • M. E. Tedder, J. Liao, B. Weed, C. Stabler*, H. Zhang*, A. Simionescu, D. Simionescu, “Stabilized collagen scaffolds for heart valve tissue engineering”, Tissue Engineering Part A, 2009, 15(6), 1257-1268.
  • T. Chuang, C. Stabler*, A. Simionescu, D. Simionescu, “Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts”, Tissue Engineering Part A, 2009, 15(10), 2837-2851.
  • M. E. Plonska-Brzezinska, A. Palkar, K. Winkler, A. Simionescu, D. Simionescu, A. Dubis, A. J. Athans, L. Echegoyen, “Small non-cytotoxic carbon nano-onions: investigation of the electrochemical behavior of CNOs film and their potential application”, in press, Chem Mater, 2010.
  • Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, D. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, Jun Liao, “Fabrication of Cardiac Patch with Decellularized Porcine Myocardial Scaffold and Bone Marrow Mononuclear Cells”, in press, Journal of Biomaterial Materials Research, part A. Dec. 2009.
  • Mary E. Tedder, Jun Liao, Agneta Simionescu, D. Simionescu, “Assembly and testing of layered collagen constructs for heart valve tissue engineering”, in press, Tissue Engineering, April 2010.
  • Leslie N. Sierad, Christopher Albers*, Jordan Maivelett*, Mary E. Tedder, Jun Liao, D. Simionescu, Agneta Simionescu, “Endothelialization of decellularized penta-galloyl-glucose treated xenograft scaffolds and dynamic conditioning in a heart valve bioreactor”, in press, Cardiovascular Engineering and Technology, May 2010.
  • Marianne B. Ariganello#, D. Simionescu, Rosalind S. Labow, J. Michael Lee, “Macrophage Differentiation and Polarization on a Decellularized Pericardial Biomaterial”, in press, Biomaterials, Aug. 2010.
  • Jeremy J. Mercuri, Sanjitpal S. Gill, D. Simionescu, “Novel Tissue-Derived Biomimetic Scaffolds for Regenerating the Human Nucleus Pulposus”, conditionally accepted, Journal of Biomaterial Materials Research, part A. Sept. 2010.
  • M. E. Plonska-Brzezinska, A. Palkar, K. Winkler, A. Simionescu, D. Simionescu, A. Dubis, A. J. Athans, L. Echegoyen, “Small non-cytotoxic carbon nano-onions: investigation of the electrochemical behavior and their potential application”, Chemistry, 16(16), 4870-4880. (2010).
  • Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, D. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, Jun Liao, “Fabrication of Cardiac Patch with Decellularized Porcine Myocardial Scaffold and Bone Marrow Mononuclear Cells”, Journal of Biomaterial Materials Research, part A., 94(4), 1100-1110 (2010).
  • Mary E. Tedder, Jun Liao, Agneta Simionescu, D. Simionescu, “Assembly and testing of layered collagen constructs for heart valve tissue engineering”, e-pub, Tissue Engineering, Sept. 2010. DOI:10.1089/ten.tea.2010.0138 
  • Leslie N. Sierad, Christopher Albers*, Jordan Maivelett*, Mary E. Tedder, Jun Liao, D. Simionescu, Agneta Simionescu, “Endothelialization of decellularized penta-galloyl-glucose treated xenograft scaffolds and dynamic conditioning in a heart valve bioreactor”, Cardiovascular Engineering and Technology, 1(2), 138-153 (2010).
  • Marianne B. Ariganello, D. Simionescu, Rosalind S. Labow, J. Michael Lee, “Macrophage Differentiation and Polarization on a Decellularized Pericardial Biomaterial”, Biomaterials, 31(36):9544-9553 (2010).
  • Jeremy J. Mercuri, Sanjitpal S. Gill, D. Simionescu, “Novel Tissue-Derived Biomimetic Scaffolds for Regenerating the Human Nucleus Pulposus”, e-pub, Journal of Biomaterial Materials Research, part A. Dec. 2010. PMID: 21154457
  • Agneta Simionescu, Mary E. Tedder, Ting-Hsien Chuang, D. Simionescu. “Lectin and Antibody-Based Histochemical Techniques For Cardiovascular Tissue Engineering”. Accepted for publication in the Journal of Histotechnology, Dec. 2010
  • M.B. Ariganello, D. Simionescu, R.S. Labow, J. Michael Lee, “Macrophage Differentiation and Polarization on a Decellularized Pericardial Biomaterial”. Biomaterials, Jan (2011) 32(2):439-49.
  • Jeremy J. Mercuri*, Sanjitpal S. Gill, Dan T. Simionescu, “Novel Tissue Derived Biomimetic Scaffold for Regenerating the Human Nucleus Pulposus”. Journal of Biomaterial Materials Research, part A. Feb (2011). 96A (2), 422–435.
  • Tedder ME, Liao J, Simionescu A, Simionescu DT, “Assembly and testing of layered collagen constructs for heart valve tissue engineering”. Tissue Engineering, Part A. (2011). 17(1-2):25-36. 
  • Agneta Simionescu, Mary E. Tedder, Ting-Hsien Chuang, D. Simionescu. “Lectin and Antibody-Based Histochemical Techniques For Cardiovascular Tissue Engineering”. Journal of Histotechnology, April (2011). 34(1):20-28.
  • Jeremy J. Mercuri, D. Simionescu, “Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration: Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration”. By invitation. Review inAdvances in Polymer Sciences, (Springer Berlin/Heidelberg), special volume on Polymers in Nanomedicine. Editor is Professor Kunugi, Kyoto, Japan, (2011). In press.
  • Agneta Simionescu, Jason Schulte, George Fercana and D. Simionescu. "Inflammation in Cardiovascular Tissue Engineering: the Challenge to a Promise". In press, International Journal of Inflammation, May (2011). 
  • Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Jun Liao. “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.” Journal of Healthcare Engineering. In review, (2011).
  • G Fercana, D Simionescu. “Polymeric Biomaterials for Vascular Tissue Engineering”. By invitation. In “Advances in Polymeric Materials”. Edited by W Shalaby and K. Burg, Taylor & Francis USA, (2011) in press.

Notes:

  • Underlined = BTRL graduate students.
  • Underlined* = BTRL undergraduate students.
  • Underlined# = PhD student in Canada,co-advised with Prof. Michael Lee, University of Dalhousie.